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Duska Separovic

Researcher at Eugene Applebaum College of Pharmacy and Health Sciences

Publications -  36
Citations -  5025

Duska Separovic is an academic researcher from Eugene Applebaum College of Pharmacy and Health Sciences. The author has contributed to research in topics: Ceramide & Sphingolipid. The author has an hindex of 17, co-authored 35 publications receiving 4080 citations. Previous affiliations of Duska Separovic include Wayne State University.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.

Duska Separovic, +14 more
- 01 May 2008 - 
TL;DR: The data show that RNA interference-dependent downregulation of SMS1 is associated with increased accumulation of ceramide and dihydroceramide with concomitant sensitization of cells to apoptosis after photodamage, and suggest that SMS is a potential novel molecular target that can augment therapeutic efficacy of PDT.
Journal ArticleDOI

De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells.

Vladislav Dolgachev, +6 more
- 28 May 2004 - 
TL;DR: These results are the first to show that in the absence of SPT up-regulation PDT induces accumulation of de novo ceramide by inhibiting its conversion to complex sphingolipids.
Journal ArticleDOI

Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage

Duska Separovic, +7 more
- 22 Jun 2007 - 
TL;DR: Overexpression of SMS1 was associated with differential regulation of sphingomyelin levels, as well as with the reduced inhibition of the enzyme post-treatment, and PDT-induced DEVDase activation was substantially reduced in SMS1-overexpressors.
Journal ArticleDOI

A role for manganese superoxide dismutase in apoptosis after photosensitization.

Vladislav Dolgachev, +7 more
- 01 Jul 2005 - 
TL;DR: The data show that MnSOD affects sensitivity of cells to Pc 4-PDT-initiated apoptosis, and partly ceramide accumulation, suggesting that the processes are superoxide-mediated.