Ted R. Hupp

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The study of lacZ transgene expression and the occurrence of apoptosis in different tissues that accumulate p53 protein point to a further level of control regulating the nature and degree of the downstream response to elevated levels of p53 in cells.

TL;DR: A direct role for p53 in signaling replicative senescence is supported and is consistent with the generation by telomere erosion of a signal which shares some but not all of the features of DNA double-strand breaks.

TL;DR: A model in which the interaction between the p53-BOX-I domain and the N terminus of MDM2 promotes conformational changes inMDM2 that stabilize acid-domain interactions with a ubiquitination signal in the DNA binding domain of the p 53 tetramer is proposed.