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Lisa M. Ellerby

Researcher at Buck Institute for Research on Aging

Publications -  122
Citations -  18411

Lisa M. Ellerby is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Huntingtin & Huntington's disease. The author has an hindex of 50, co-authored 114 publications receiving 16680 citations. Previous affiliations of Lisa M. Ellerby include University of California, Los Angeles & University of California.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Bax directly induces release of cytochrome c from isolated mitochondria

Juliane M. Jürgensmeier, +5 more
- 28 Apr 1998 - 
TL;DR: It is shown that addition of submicromolar amounts of recombinant Bax protein to isolated mitochondria can induce cytochrome c (Cyt c) release, whereas a peptide representing the Bax BH3 domain was inactive, implying that Bax uses an alternative mechanism for triggering release of Cyt c from mitochondria.
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Coupling Endoplasmic Reticulum Stress to the Cell Death Program MECHANISM OF CASPASE ACTIVATION

Rammohan V. Rao, +6 more
- 07 Sep 2001 - 
TL;DR: It is proposed that any cellular insult that causes prolonged ER stress may induce apoptosis through caspase-7-mediated casp enzyme-12 activation, and the data underscore the involvement of ER and caspases associated with it in the ER stress-induced apoptotic process.
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Encapsulation of proteins in transparent porous silicate glasses prepared by the sol-gel method

Lisa M. Ellerby, +6 more
- 28 Feb 1992 - 
TL;DR: Novel sol-gel synthetic techniques were used to immobilize copper-zinc superoxide dismutase, cytochrome c, and myoglobin by encapsulation in stable, optically transparent, porous silica glass matrices under mild conditions such that the biomolecules retained their characteristic reactivities and spectroscopic properties.
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Lysosomal Protease Pathways to Apoptosis: CLEAVAGE OF Bid, NOT PRO-CASPASES, IS THE MOST LIKELY ROUTE *

Veronika Stoka, +16 more
- 02 Feb 2001 - 
TL;DR: Data suggest that Bid represents a sensor that allows cells to initiate apoptosis in response to widespread adventitious proteolysis, supported by the finding that cytosolic extracts from mice ablated in the bid gene are impaired in the ability to release cytochrome c in Response to lysosome extracts.