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Frédéric Bost

Researcher at French Institute of Health and Medical Research

Publications -  92
Citations -  11773

Frédéric Bost is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 38, co-authored 84 publications receiving 10114 citations. Previous affiliations of Frédéric Bost include Sanford-Burnham Institute for Medical Research & National Institutes of Health.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

I. Ben Sahra, +16 more
- 05 Jun 2008 - 
TL;DR: Oral and intraperitoneal treatment with metformin led to a 50 and 35% reduction of tumor growth, respectively, in mice bearing xenografts of LNCaP, providing evidence for a mechanism that may contribute to the antineoplastic effects of met formin suggested by recent epidemiological studies.
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Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

Isaam Ben Sahra, +8 more
- 01 Jul 2011 - 
TL;DR: RedD1 (also known as DDIT4 and RTP801), a negative regulator of mTOR, is identified as a new molecular target of metformin and inhibition of REDD1 reverses meetformin-induced cell-cycle arrest and significantly protects from the deleterious effects of met formin on cell transformation.
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The role of MAPKs in adipocyte differentiation and obesity.

Frédéric Bost, +3 more
- 01 Jan 2005 - 
TL;DR: It appears now that a fine tuning of the MAPKs regulates both normal and pathological adipogenesis, and the precise understanding of the cascade of these molecular events and the way to regulate them will be certainly crucial in order to efficiently fight obesity.
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Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

Issam Ben Sahra, +13 more
- 15 Mar 2010 - 
TL;DR: The combination of metformin and 2DG inhibited mitochondrial respiration and glycolysis in prostate cancer cells leading to a severe depletion in ATP and induced p53-dependent apoptosis and triggered a switch from a survival process to cell death.