Feng Feng Tian

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Evidence of in vivo autophagy detection, with a peak at 1 d, in a live animal model following cerebral ischemia is provided, which could be valuable for monitoring autophagic processes in vivo in live stroke patients, as well as for clarifying the detailed role of autophaging in the ischemic brain, as in other neurological diseases.

TL;DR: Ex vivo autophagy imaging of spinal cord sections showed a progressive increase of the fluorescence signal from 17 to 19 weeks in DTg mice in the anterior horn at the L4-5 level, and fluorescence signals were clearly observed in the gray matter of the spinal cord with a progressive increased of the signal and decreases in large motor neurons.

TL;DR: A correlation between in vivo optical imaging of MMP activation and the improvement of ischemic brain damage caused by tPA after tMCAO is provided and treated by BMSC and EDA.