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G. Angus McQuibban

Researcher at University of Toronto

Publications -  31
Citations -  6559

G. Angus McQuibban is an academic researcher from University of Toronto. The author has contributed to research in topics: Mitophagy & Mitochondrion. The author has an hindex of 19, co-authored 27 publications receiving 5361 citations. Previous affiliations of G. Angus McQuibban include Laboratory of Molecular Biology.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

G. Angus McQuibban, +2 more
- 29 May 2003 - 
TL;DR: The data indicate that mitochondrial membrane remodelling is regulated by cleavage of Mgm1p and show that intramembrane proteolysis by rhomboids controls cellular processes other than signalling, suggesting that these proteins represent a functionally conserved subclass of rhomboid proteases.
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ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

Yuqing Wang, +4 more
- 14 Aug 2012 - 
TL;DR: It is shown that elongated mitochondria are more resistant to ROS-induced damage and mitophagy compared with fragmented mitochondria, suggesting that mitochondrial morphology has an important role in regulating ROS andMitophagy.
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Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.

Alexander J. Whitworth, +5 more
- 01 Sep 2008 - 
TL;DR: The involvement of the mitochondrial protease encoded by omi in the Pink1/Parkin pathway is investigated and it is found that it acts genetically downstream of pink1 but functions independently of Parkin, suggesting that regulated intramembrane proteolysis is involved in its regulation.
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Deubiquitinating enzymes regulate PARK2-mediated mitophagy

Yuqing Wang, +7 more
- 27 Apr 2015 - 
TL;DR: 2 mitochondrial DUBs, USP30 and USP35, regulate PARK2-mediated mitophagy, and this study provides clear rationales for the design and development of drugs for the therapeutic treatment of neurodegenerative diseases such as Parkinson and Alzheimer diseases.