David L. Boone

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A20 is critical for limiting inflammation by terminating TNF-induced NF-kappaB responses in vivo and is associated with severe inflammation and cachexia in mice deficient for A20.

TL;DR: IL-15Ralpha has pleiotropic roles in immune development and function, including the positive maintenance of lymphocyte homeostasis, and is generated in mice deficient in natural killer cells, natural killer T cells, CD8+ T lymphocytes, and TCRgammadelta intraepithelial lymphocytes.

TL;DR: Results show that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time.

TL;DR: It is found that adoptive transfer of normal NK cells into mice lacking the high affinity interleukin (IL)-15 receptor, IL-15Rα, surprisingly results in the abrupt loss of these cells, and it is demonstrated that NK cell–independent IL- 15Rα expression is critical for maintaining peripheral NK cells, while IL-13R α expression on NK cells is not required for this function.