William A. Weiss

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is found that p110alpha is the primary insulin-responsive PI3-K in cultured cells, whereas p110beta is dispensable but sets a phenotypic threshold for p110 alpha activity, which illustrates systematic target validation using a matrix of inhibitors that span a protein family.

TL;DR: Exome sequencing of exomes of 23 initial low-grade gliomas and recurrent tumors resected from the same patients suggests that recurrent tumors are often seeded by cells derived from the initial tumor at a very early stage of their evolution.

TL;DR: Investigation of the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells suggests that targeted delivery of microRNA-124 and/or micro RNA-137 to gliobeasts tumor cells may be therapeutically efficacious for the treatment of this disease.

TL;DR: The current understanding of the core components of the autophagy machinery and the functional relevance of autophile within the tumor microenvironment is described and how this knowledge has informed preclinical investigations combining the autophile inhibitor hydroxychloroquine (HCQ) with chemotherapy, targeted therapy, and immunotherapy is outlined.