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John Tower

Researcher at University of Southern California

Publications -  103
Citations -  11281

John Tower is an academic researcher from University of Southern California. The author has contributed to research in topics: Gene & Drosophila melanogaster. The author has an hindex of 44, co-authored 100 publications receiving 9843 citations. Previous affiliations of John Tower include Carnegie Institution for Science & Johns Hopkins University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

Jingtao Sun, +1 more
- 01 Jan 1999 - 
TL;DR: Yeast FLP recombinase was used in a binary transgenic system to allow induced overexpression of catalase and/or Cu/Zn-superoxide dismutase and the data suggest that oxidative damage is one rate-limiting factor for the life span of adult Drosophila.
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Superoxide dismutase evolution and life span regulation.

Gary N. Landis, +1 more
- 01 Mar 2005 - 
TL;DR: Genetic and transgenic manipulation of SOD activities in model systems such as S. cereviseae, mouse and Drosophila are consistent with a central role for SOD enzymes in regulating oxidative stress resistance, and a phylogenetic analysis of publicly available SOD protein sequences suggests several additional conserved gene families.
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Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster.

Jingtao Sun, +3 more
- 01 Jun 2002 - 
TL;DR: For both MnSOD and Cu/ZnSOD lines, increased life span was not associated with decreased metabolic activity, as measured by O2 consumption, and was consistent with previous observations that catalase is present in excess in the adult fly with regard to life span.
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Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster

Gary N. Landis, +7 more
- 18 May 2004 - 
TL;DR: Immune reporter expression in young flies was partially predictive of remaining life span, suggesting their potential as biomonitors of aging, and a recently developed background correction algorithm and robust multichip model-based statistical analysis dramatically increased the ability to identify changes in gene expression.