Rosa Salvioli

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Recent findings on the structure of saposins and on their interactions with lipids, with special attention to interactions with phospholipids offer a new approach for understanding the physiological role of saPOSins in lysosomes.

TL;DR: The finding that an acidic environment induces an increased hydrophobicity in Sap A, C, and D, making the last two saposin able to interact and perturb phospholipid membranes, suggests that this mechanism might be relevant to the mode of action of saposins in lysosomes.

TL;DR: A correlation was observed between the type of Sap C mutation and the Gaucher phenotype: apparently, mutations involving cysteine residues lead to a neurological variant of GD.