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Karen Duff

Researcher at University College London

Publications -  187
Citations -  35244

Karen Duff is an academic researcher from University College London. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 87, co-authored 180 publications receiving 31810 citations. Previous affiliations of Karen Duff include Mayo Clinic & Columbia University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

Dave Morgan, +14 more
- 21 Dec 2000 - 
TL;DR: It is shown that vaccination with Aβ protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease and may prevent and, possibly, treat Alzheimer's dementia.
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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Karen Duff, +21 more
- 24 Oct 1996 - 
TL;DR: Results indicate that the presenilin mutations probably cause Alzheimer's disease through a gain of deleterious function that increases the amount of Aβ42(43) in the brain.
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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Leigh A. Holcomb, +18 more
- 01 Jan 1998 - 
TL;DR: The development of AD-like pathology is substantially enhanced when a P51 mutation, which causes a modest increase in Aβ42(43), is introduced into Tg2576-derived mice, and both doubly and singly transgenic mice showed reduced spontaneous alternation performance in a “Y” maze before substantial Aβ deposition was apparent.
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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.

Jada Lewis, +17 more
- 01 Aug 2000 - 
TL;DR: The phenotype of mice expressing P301L mutant tau mimics features of human tauopathies and provides a model for investigating the pathogenesis of diseases with NFT.