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Jean-Pierre Bourquin

Researcher at Boston Children's Hospital

Publications -  158
Citations -  10392

Jean-Pierre Bourquin is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Leukemia & Transplantation. The author has an hindex of 37, co-authored 141 publications receiving 8206 citations. Previous affiliations of Jean-Pierre Bourquin include Harvard University & Sapienza University of Rome.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

Dani Bercovich, +28 more
- 25 Oct 2008 - 
TL;DR: In this article, mutations in JAK2 might be a common molecular event in acute lymphoblastic leukaemia associated with Down's syndrome, and the functional consequences of identified mutations were studied in mouse haematopoietic progenitor cells.
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A Mass Spectrometric-Derived Cell Surface Protein Atlas

Damaris Bausch-Fluck, +20 more
- 20 Apr 2015 - 
TL;DR: In this paper, the authors applied the Cell Surface Capture (CSC) technology to 41 human and 31 mouse cell types to generate a mass-spectrometry derived Cell Surface Protein Atlas (CSPA) providing cellular surfaceome snapshots at high resolution.
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Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

Libi Hertzberg, +31 more
- 04 Feb 2010 - 
TL;DR: The data suggest that the majority of DS children with ALL may benefit from therapy blocking the CRLF2/JAK2 pathways, and the gene expression signature of DS-ALL is enriched with DNA damage and BCL6 responsive genes, suggesting the possibility of B-cell lymphocytic genomic instability.
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Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

Laura Bonapace, +9 more
- 01 Apr 2010 - 
TL;DR: Complete resensitization of multidrug-resistant childhood ALL cells to glucocorticoids and other cytotoxic agents with subcytotoxic concentrations of obatoclax, a putative antagonist of BCL-2 family members is reported.