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Jason E. Gestwicki

Researcher at University of California, San Francisco

Publications -  280
Citations -  27231

Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Potential therapeutic applications of autophagy.

David C. Rubinsztein, +3 more
- 01 Apr 2007 - 
TL;DR: A better understanding of autophagy is needed to allow its manipulation for therapeutic purposes, and new insights into the molecular mechanisms are now leading to the discovery of exciting new potential drug targets.
Journal ArticleDOI

Synthetic Multivalent Ligands as Probes of Signal Transduction

Laura L. Kiessling, +3 more
- 03 Apr 2006 - 
TL;DR: This Review focuses on the use of synthetic multivalent ligands to characterize receptor function through chemical synthesis to address the role of receptor assembly in signal transduction.
Journal ArticleDOI

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

Jason E. Gestwicki, +4 more
- 22 Nov 2002 - 
TL;DR: It is found that ligands with certain architectures are effective inhibitors, but others mediate receptor clustering, whereas linear oligomeric ligands generated by the ring-opening metathesis polymerization have structural properties that favor clustering.