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Zhonglin Xie

Researcher at University of Oklahoma Health Sciences Center

Publications -  38
Citations -  13618

Zhonglin Xie is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: AMPK & AMP-activated protein kinase. The author has an hindex of 30, co-authored 33 publications receiving 11938 citations. Previous affiliations of Zhonglin Xie include University of Oklahoma.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

Bradley J. Davis, +3 more
- 01 Feb 2006 - 
TL;DR: Results indicate that metformin might improve vascular endothelial functions in diabetes by increasing AMPK-dependent, hsp90-mediated eNOS activation.
Journal ArticleDOI

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

Zhonglin Xie, +11 more
- 01 Jun 2011 - 
TL;DR: Investigating whether chronic activation of the AMP-activated protein kinase (AMPK) by metformin restores cardiac function and cardiomyocyte autophagy in OVE26 diabetic mice found that stimulation of AMPK may represent a novel approach to treat diabeticCardiomyopathy.
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Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes.

Chaoyong He, +4 more
- 01 Apr 2013 - 
TL;DR: Dissociation of Bcl-2 from Beclin1 may be an important mechanism for preventing diabetic cardiomyopathy via AMPK activation that restores autophagy and protects against cardiac apoptosis.