Molly L. Bristol

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The current studies are consistent with the premise that while autophagy mediates a cytoprotective function in irradiated breast tumor cells, promotion of autophagic can also confer radiosensitivity by vitamin D (1,25D3).

TL;DR: Autophagy and senescence tend to occur in parallel, and furthermore that autophagy accelerates the development of the senescent phenotype, however, these responses are not inexorably linked or interdependent.

TL;DR: These studies support the potential utility of vitamin D for improving the impact of radiation for breast cancer therapy, support the feasibility of combining chloroquine with radiation for the treatment of breast cancer, and demonstrate the existence of an “autophagic switch” from cytoprotective autophagy with radiation alone to cytotoxic autophagic with the 1,25 D3–radiation combination.

TL;DR: It is demonstrated that the Aurora Kinase A inhibitor MLN8237 combines with ABT-199 to induce widespread apoptosis, and in diverse models of MYCN-amplified neuroblastoma, this combination uniformly induced tumor shrinkage and in multiple instances led to complete tumor regression.