Katie Marchbank

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: MINT‐7034220: NBR1 physically interacts with ube2o (uniprotkb:Q6ZPJ3) by two hybrid by two hybrids.

TL;DR: It is shown that genetic truncation of murine Nbr1 leads to an age-dependent increase in bone mass and bone mineral density through increased osteoblast differentiation and activity and pharmacological inhibition of the p38 MAPK pathway in vitro abrogates the increased osteOBlast differentiation of N br1tr/tr cells.

TL;DR: This study demonstrates an interaction between the evolutionarily conserved FW domain of Nbr1 with the microtubule-associated protein MAP1B, the first evidence that links the ubiquitin receptor NBR1, which shuttles ubiquitinated proteins to be degraded by autophagy, to the micro Tubule network.

TL;DR: It is shown that truncation of Nbr1 in a murine model, where it can still interact with p62 but not LC3, leads to increased osteoblast differentiation and activity in vivo, which results in an age-dependent increase in bone mass and bone mineral density.