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Albert R. La Spada

Researcher at Duke University

Publications -  168
Citations -  22034

Albert R. La Spada is an academic researcher from Duke University. The author has contributed to research in topics: Neurodegeneration & Spinocerebellar ataxia. The author has an hindex of 53, co-authored 155 publications receiving 19250 citations. Previous affiliations of Albert R. La Spada include University of California & University of California, Irvine.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.

Albert R. La Spada, +4 more
- 04 Jul 1991 - 
TL;DR: It is concluded that enlargement of the CAG repeat in the androgen receptor gene is probably the cause of X-LINKED spinal and bulbar muscular atrophy.
Journal ArticleDOI

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

Patrick Weydt, +18 more
- 01 Nov 2006 - 
TL;DR: Reduced expression of PGC-1alpha target genes in HD patient and mouse striatum is document, which may link transcription dysregulation and mitochondrial dysfunction in HD.
Journal ArticleDOI

Repeat expansion disease: progress and puzzles in disease pathogenesis.

Albert R. La Spada, +2 more
- 23 Feb 2010 - 
TL;DR: Investigation of the polyglutamine diseases has identified post-translational modification as a key step in the pathogenic cascade and has shown that the autophagy pathway has an important role in the degradation of misfolded proteins — two themes that are likely to be relevant to the entire neurodegeneration field.