Yuqing Wang

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that elongated mitochondria are more resistant to ROS-induced damage and mitophagy compared with fragmented mitochondria, suggesting that mitochondrial morphology has an important role in regulating ROS andMitophagy.

TL;DR: Results suggest that NBR1 is the specific autophagy receptor for pexophagy, and that substrate selectivity is partly achieved by N BR1 itself by coincident binding of the J and UBA domains to peroxisomes.

TL;DR: This study reports that the ER-resident VAMP-associated proteins A and B interact with the peroxisomal membrane protein acyl-CoA binding domain containing 5 (ACBD5) and that this interaction is required to tether the two organelles together, thereby facilitating the lipid exchange between them.

TL;DR: 2 mitochondrial DUBs, USP30 and USP35, regulate PARK2-mediated mitophagy, and this study provides clear rationales for the design and development of drugs for the therapeutic treatment of neurodegenerative diseases such as Parkinson and Alzheimer diseases.