Aleksandra Isakovic

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Unlike polyhydroxylated C60 that exerts mainly antioxidant/cytoprotective and only mild ROS-independent pro-apoptotic activity, pure crystalline C60 seems to be endowed with strong pro-oxidant capacity responsible for the rapid necrotic cell death.

TL;DR: Investigating the requirements for the reactive oxygen species (ROS)-mediated cytotoxicity of different nC(60) suspensions, prepared by solvent exchange method in tetrahydrofuran and ethanol and by extended mixing in water, indicates that the (1)O(2)-quenching power of the solvent intercalated in the fullerene crystals determines their ability to produce ROS and cause cell damage.

TL;DR: The multiple mechanisms underlying the in vitro anticancer effects of the C(60) fullerene water suspension are demonstrated and primary rat astrocytes were less sensitive than their transformed counterparts to a cytostatic action of low-dose nC(60).

TL;DR: The beneficial effect of betaine in MCD‐induced NAFLD is associated with the reduction of liver oxidative stress, inflammation, and apoptosis, and the increase in cytoprotective Akt/mTOR signaling and autophagy.