scispace - formally typeset
G

Gijs R. van den Brink

Researcher at University of Amsterdam

Publications -  66
Citations -  8096

Gijs R. van den Brink is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Stem cell & Intestinal epithelium. The author has an hindex of 31, co-authored 66 publications receiving 7029 citations. Previous affiliations of Gijs R. van den Brink include University of Adelaide & GlaxoSmithKline.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

Jarom Heijmans, +18 more
- 25 Apr 2013 - 
TL;DR: It is shown that in normal intestinal epithelium, endoplasmic reticulum stress and activity of the unfolded protein response (UPR) are induced at the transition from stem cell to transit-amplifying cell transition.
Journal ArticleDOI

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

Anne Christine W. Vos, +11 more
- 01 Mar 2012 - 
TL;DR: Data show that regulatory macrophages may be involved in mucosal healing and provide a rationale for the superiority of infliximab/azathioprine combination treatment observed in the clinic.
Journal ArticleDOI

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Philip W. Voorneveld, +18 more
- 01 Jul 2014 - 
TL;DR: Loss of SMAD4 from colorectal tumors causes BMP signaling to switch from tumor suppressive to metastasis promoting, and reagents that interfere with SMad4-independent B MP signaling, such as ROCK inhibitors, might be developed as therapeutics for CRC.
Journal ArticleDOI

Blimp1 regulates the transition of neonatal to adult intestinal epithelium.

Vanesa Muncan, +19 more
- 30 Aug 2011 - 
TL;DR: It is shown that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition, and deletion of Blimp1 results in growth retardation and excessive neonatal mortality in Mutant mice.