Marco Folini

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Overall, it is shown for the first time that miR-205 exerts a tumor-suppressive effect in human prostate by counteracting epithelial-to-mesenchymal transition and reducing cell migration/invasion, at least in part through the down-regulation of protein kinase Cepsilon.

TL;DR: Survivin is a bifunctional protein that acts as a suppressor of apoptosis and plays a central role in cell division and has been proposed as an attractive target for new anticancer interventions as discussed by the authors.

TL;DR: Evidence is provided that miR-21 knockdown in prostate cancer cells is not sufficient per se to affect the proliferative and invasive potential or the chemo- and radiosensitivity profiles, which supports the notion that the oncogenic properties of mi R-21 could be cell and tissue dependent and that the potential role of a given miRNA as a therapeutic target should be contextualized with respect to the disease.

TL;DR: Several preclinical studies have demonstrated that downregulation of survivin expression or function, accomplished by means of various strategies, reduced tumor growth potential, increased the apoptotic rate and sensitized tumor cells to chemotherapeutic drugs and radiation in different human tumor models.