Zhiyuan Yao

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This review focuses on macroautophagy, briefly describing the discovery of this process in mammalian cells, discussing the current views concerning the donor membrane that forms the phagophore, and characterizing the autophagy machinery including the available structural information.

TL;DR: The current state of knowledge concerning transcriptional, post-transcriptional, and post- translational regulation of autophagy in yeast and mammals is focused on.

TL;DR: This work identified the yeast protein Icy2, which is now name Atg41, as playing a role in autophagosome formation, and provides further insight into the mechanism of Atg9 function and the dynamics of sequestering membrane formation during autophagy.