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Lydia Alvarez-Erviti

Researcher at University College London

Publications -  38
Citations -  12724

Lydia Alvarez-Erviti is an academic researcher from University College London. The author has contributed to research in topics: Alpha-synuclein & Neurodegeneration. The author has an hindex of 18, co-authored 34 publications receiving 10630 citations. Previous affiliations of Lydia Alvarez-Erviti include University of Oxford & UCL Institute of Neurology.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti, +5 more
- 01 Apr 2011 - 
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander, +17 more
- 20 Apr 2015 - 
TL;DR: This is the first extensive biodistribution investigation of EVs comparing the impact of several different variables, the results of which have implications for the design and feasibility of therapeutic studies using EVs.
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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Lydia Alvarez-Erviti, +6 more
- 01 Jun 2011 - 
TL;DR: This study demonstrates the importance of exosomes in both the release of alpha synuclein and its transmission between cells and suggests that factors associated with PD pathology accelerate this process.
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Exosome-mediated delivery of siRNA in vitro and in vivo

Samir El-Andaloussi, +9 more
- 01 Dec 2012 - 
TL;DR: This protocol describes the generation of targeted exosomes through transfection of an expression vector, comprising an exosomal protein fused with a peptide ligand, and details crucial steps for loading siRNA into exosome.