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Rolf J. Craven

Researcher at University of Kentucky

Publications -  77
Citations -  10599

Rolf J. Craven is an academic researcher from University of Kentucky. The author has contributed to research in topics: Tyrosine kinase & PGRMC1. The author has an hindex of 41, co-authored 75 publications receiving 9885 citations. Previous affiliations of Rolf J. Craven include University of Guelph & Leiden University Medical Center.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal Article

Overexpression of the Focal Adhesion Kinase (p125FAK) in Invasive Human Tumors

Lewis V. Owens, +8 more
- 01 Jul 1995 - 
TL;DR: Evidence that both epithelial and mesenchymal tumor progression are accompanied by increased p125FAK expression is provided and it is suggested that the level of FAK expression might be a marker for the invasive potential of a tumor.
Journal ArticleDOI

Expression of focal adhesion kinase gene and invasive cancer

Timothy M. Weiner, +3 more
- 23 Oct 1993 - 
TL;DR: Increased levels of FAK overexpression are found in 1 of 8 adenomatous tissues, in 17 of 20 invasive tumours, and in all 15 metastatic tumours to suggest thatFAK overeexpression may accompany changes in signal pathways involved in tumour cell invasion.
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Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

Nicholas J. Izzo, +22 more
- 12 Nov 2014 - 
TL;DR: It is proposed that sigma-2/PGRMC1 receptors mediate saturable oligomer binding to synaptic puncta on neurons and that brain penetrant, small molecules can displace endogenous and synthetic oligomers and improve cognitive deficits in AD models.
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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

Eun Kyoung Yim, +10 more
- 07 Apr 2009 - 
TL;DR: It is demonstrated that the Rak tyrosine kinase physically interacts with PTEN and phosphorylates PTEN on Tyr336 and acts as a bona fide tumor suppressor gene through the mechanism of regulating PTEN protein stability and function.