Hongwei Xu

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that Aβ-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Aβ to mitochondrial toxicity and the ABAD-Aβ interaction may be a therapeutic target in Alzheimer's disease.

TL;DR: It is demonstrated that intracellular Aβ is present in mitochondria from brains of transgenic mice with targeted neuronal overexpression of mutant human amyloid precursor protein and AD patients, delineating a new means through which Aβ potentially impairs neuronal energetics, contributing to cellular dysfunction in AD.

TL;DR: It is concluded that blockade of microglial RAGE may have a beneficial effect on Aβ‐mediated neuronal perturbation relevant to AD pathogenesis, and introduction of a signal transduction‐defective mutant RAGE to microglia attenuates deterioration induced by Aβ.

TL;DR: Findings link ABAD‐induced oxidant stress to critical aspects of Alzheimer's disease (AD)‐associated cellular dysfunction, suggesting a pivotal role for this enzyme in the pathogenesis of AD.