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Katherine L. Cook

Researcher at Wake Forest University

Publications -  82
Citations -  7428

Katherine L. Cook is an academic researcher from Wake Forest University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 24, co-authored 59 publications receiving 6468 citations. Previous affiliations of Katherine L. Cook include University of Washington & Georgetown University Medical Center.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate

Robert Clarke, +11 more
- 15 Mar 2012 - 
TL;DR: The unfolded protein response, autophagy, and apoptosis are described, and how the regulation of these processes is integrated are discussed.
Journal ArticleDOI

Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer

Katherine L. Cook, +6 more
- 15 Jun 2014 - 
TL;DR: It is shown that CQ can increase antiestrogen responsiveness in MCF7-RR and LCC9 cells and tumors, likely through the inhibition of autophagy, and the beneficial combination of TAM+CQ suggests a positive outcome for ongoing neoadjuvant clinical trials using this combination for the treatment of ER+ ductal carcinoma in situ lesions.
Journal ArticleDOI

Autophagy and endocrine resistance in breast cancer.

Katherine L. Cook, +2 more
- 01 Aug 2011 - 
TL;DR: The complex and occasionally contradictory roles of autophagy in cancer and in resistance to endocrine therapies in breast cancer are discussed.
Journal ArticleDOI

Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.

Katherine L. Cook, +5 more
- 01 Jul 2012 - 
TL;DR: A novel role for GRP78 is revealed in the integration of cellular signaling pathways including the unfolded protein response, apoptosis, and autophagy to determine cell fate in response to antiestrogen therapy.