Beata Pajak

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Attempts to improve 2-DG’s drug-like properties, its role as a potential adjuvant for other chemotherapeutics, and novel 2- DG analogs as promising new anticancer agents are discussed in this review.

TL;DR: Unique properties of PN make this agent a promising metabolic inhibitor to retard tumorigenesis and to suppress tumor growth and advances in molecular biology indicate that this sesquiterpene lactone might evoke the above-mentioned effects by indirect action on genes.

TL;DR: Unique properties of NaBt make this agent a promising metabolic inhibitor to retard tumorigenesis to suppress tumor growth and to ampify the apoptotic signals.

TL;DR: In this paper, a review outlines the molecular events that accompany the antitumor action of sodium butyrate (NaBt), including higher expression of membrane death receptors (DR4/5), higher level and activation of Smad3 protein in TGF-beta-dependent apoptotic pathway, lower level of anti-apoptotic proteins (cFLIP, XIAP) and activations of Proap-optotic tBid protein.