scispace - formally typeset
R

Rubén Gómez-Sánchez

Researcher at University Medical Center Groningen

Publications -  41
Citations -  6567

Rubén Gómez-Sánchez is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 19, co-authored 40 publications receiving 5850 citations. Previous affiliations of Rubén Gómez-Sánchez include Utrecht University & University of Extremadura.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores.

Rubén Gómez-Sánchez, +12 more
- 06 Aug 2018 - 
TL;DR: Light is shed in the interrelationship between Atg9, Atg2, and Atg18 and the possible functional relevance of the phagophore–ER contact sites in phagophile expansion is highlighted.
Journal ArticleDOI

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.

José Manuel Bravo-San Pedro, +11 more
- 01 Jan 2013 - 
TL;DR: Data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagic activity reduces the sensitivity observed in G 2019S mutant cells.
Journal ArticleDOI

Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.

Mireia Niso-Santano, +10 more
- 15 May 2010 - 
TL;DR: This study identifies ASK 1/JNK and ASK1/p38 as two critical pathways involved in the activation of cell death under oxidative stress conditions and identifies the Nrf2/Trx axis as a new target to block these pathways and protect from oxidant exposure such as that found in Parkinson and other neurodegenerative diseases.
Journal ArticleDOI

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.

Wondwossen M Yeshaw, +12 more
- 11 Feb 2019 - 
TL;DR: It is demonstrated that VPS13A is a peripheral membrane protein, associated with mitochondria, the endoplasmic reticulum and lipid droplets, and required for lipid transfer required for mitochondria and lipid Droplet related processes.