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Linghua Meng

Researcher at Chinese Academy of Sciences

Publications -  116
Citations -  8718

Linghua Meng is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Topoisomerase. The author has an hindex of 31, co-authored 108 publications receiving 7807 citations. Previous affiliations of Linghua Meng include Nanjing University of Chinese Medicine & National Institutes of Health.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Repair of and checkpoint response to topoisomerase I-mediated DNA damage.

Yves Pommier, +11 more
- 27 Nov 2003 - 
TL;DR: Defects in these repair/checkpoint pathways, which promote tumor development, explain the selectivity of camptothecins and other Top1 inhibitors for cancer cells.
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A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity

He Huang, +13 more
- 30 Mar 2010 - 
TL;DR: Results about the mechanisms involved in the anticancer activities of thiosemicarbazones will aid in the rational design of novel topoisomerase II-targeted drugs and will provide insights into the discovery and development of novel cancer therapeutics based on the dual activity to chelate iron and to inhibit the catalytic activity of topoisomersase IIalpha.
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Emerging cancer therapeutic opportunities target DNA-repair systems

Jian Ding, +3 more
- 01 Jun 2006 - 
TL;DR: DNA-damaging agents have a central role in non-surgical cancer treatment and an elevated DNA-repair capacity in tumor cells leads to drug or radiation resistance and severely limits the efficacy of these agents.
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Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

H. Takemura, +7 more
- 13 Oct 2006 - 
TL;DR: It is proposed that Mre11 stabilizes Nbs1 and Rad50 and that MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks.