Yacine Graba

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: How previously identified histone acetylases and deacetylases modify key autophagic effector proteins are summarized and discussed, and how this has an impact on physiological and pathological cellular processes are discussed.

TL;DR: The molecular and cellular scale mechanisms underlying the diverse roles of the Hox transcription factors during morphogenesis and organogenesis are discussed.

TL;DR: It is shown that Drosophila Hox proteins are potent repressors of the autophagic process, and that temporality is controlled by Pontin, a facultative component of the Brahma chromatin remodeling complex, which indicates that regulation of autophagy is an evolutionary conserved feature of H Cox proteins.

TL;DR: Linking transcription factors, PcG proteins and paused Pol II states, these data identify a two‐step mechanism of Hox‐driven transcription, with M1BP binding leading to Pol II recruitment followed by AbdA targeting, which results in a change in the chromatin landscape and enhanced transcription.