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Lei Jin

Researcher at University of Newcastle

Publications -  76
Citations -  8315

Lei Jin is an academic researcher from University of Newcastle. The author has contributed to research in topics: Melanoma & Downregulation and upregulation. The author has an hindex of 29, co-authored 65 publications receiving 7263 citations. Previous affiliations of Lei Jin include Kolling Institute of Medical Research & Dalian Medical University.

Papers
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Regulation of PD-L1: a novel role of pro-survival signalling in cancer

Jiezhong Chen, +4 more
- 01 Mar 2016 - 
TL;DR: The recent progress of the regulation of PD-L1 expression in cancer cells is summarized, a regulatory model for unified explanation is proposed and Clinically, it could increase treatment efficacy of targeted therapy by choosing those molecules that control both PD- L1 expression and cell proliferation.
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GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability.

Wang Lai Hu, +8 more
- 28 Mar 2018 - 
TL;DR: It is demonstrated that the p53-responsive lncRNA GUARDIN is important for maintaining genomic integrity under steady-state conditions and after exposure to exogenous genotoxic stress and may constitute a target for cancer treatment.
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MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.

Guo St, +12 more
- 11 Apr 2013 - 
TL;DR: Downregulation of microRNA-497 (miR-497) as a result of DNA copy number reduction is involved in upregulation of IGF1-R in CRC cells that contributes to malignancy of CRC.
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MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma

Lei Jin, +12 more
- 20 Sep 2011 - 
TL;DR: It is shown that p53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3α, resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells.