Christopher J. H. Elliott

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The conclusions derived from studies on gastropod feeding are generally consistent with those from other systems, but often provide more detailed information on the behavioural function of a particular property of the nervous system.

TL;DR: A new model of tissue-specific actions of octopamine is proposed, in which strengthening of peritoneal sheath contractions, coupled with relaxation of the oviduct, eases ovulation in female flies with mutations in the octopaminergic system.

TL;DR: Data suggest that dysfunction of Drosophila TDP-43 triggers a cascade of events leading to loss-of-function phenotypes whereby impaired synaptic transmission results in defective motor behavior and progressive deconstruction of neuronal connections, ultimately causing age-related neurodegeneration.

TL;DR: There is clear preclinical impairment of mitochondrial function in NM-LRRK2G 2019S that is distinct from the mitochondrial impairment observed in parkin-related PD, and the beneficial effect of UDCA on mitochondrial function as well as on the function of dopaminergic neurons expressing LRRK 2G2019S suggests that UDCA is a promising drug for future neuroprotective trials.