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Benjamin R. Underwood

Researcher at University of Cambridge

Publications -  38
Citations -  8985

Benjamin R. Underwood is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 12, co-authored 22 publications receiving 8229 citations. Previous affiliations of Benjamin R. Underwood include National Health Service & Fulbourn Hospital.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Brinda Ravikumar, +18 more
- 01 Oct 2010 - 
TL;DR: This review focuses on mammalian autophagy, and an overview of the understanding of its machinery and the signaling cascades that regulate it is given, and the possibility of autophagic upregulation as a therapeutic approach for various conditions is considered.
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Rapamycin alleviates toxicity of different aggregate-prone proteins.

Zdenek Berger, +10 more
- 01 Feb 2006 - 
TL;DR: The studies suggest that the scope for rapamycin as a potential therapeutic in aggregate diseases may be much broader than HD or even polyglutamine diseases.
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Huntington's disease: from pathology and genetics to potential therapies.

Sara Imarisio, +10 more
- 01 Jun 2008 - 
TL;DR: Not all of the effects of mutant huntingtin may be cell-autonomous, and it is possible that abnormalities in neighbouring neurons and glia may also have an impact on connected cells.
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Complex Inhibitory Effects of Nitric Oxide on Autophagy

Sovan Sarkar, +12 more
- 08 Jul 2011 - 
TL;DR: The data suggest that nitrosative stress-mediated protein aggregation in neurodegenerative diseases may be, in part, due to autophagy inhibition.