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Carole Kretz-Remy

Researcher at Centre national de la recherche scientifique

Publications -  6
Citations -  6397

Carole Kretz-Remy is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Oxidative stress & Hsp27. The author has an hindex of 6, co-authored 6 publications receiving 5920 citations. Previous affiliations of Carole Kretz-Remy include University of Lyon.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death

TL;DR: The results suggest that the protective activity shared by human hsp27, Drosophila hsp 27 and human alphaB‐crystallin against TNFalpha‐mediated cell death and probably other types of oxidative stress results from their conserved ability to raise the intracellular concentration of glutathione.
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Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.

TL;DR: It is suggested that intracellular ROS are key elements that regulate the phosphorylation of I kappa B-alpha, a phenomenon that precedes and controls the degradation of this protein, and then NF-kappa B activation.
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Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels.

TL;DR: An analysis of several Hsp27 mutants that suggests that the C-terminal part of this stress protein is essential for its protective activity against oxidative stress.
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NF-κB regulates protein quality control after heat stress through modulation of the BAG3–HspB8 complex

TL;DR: NF-κB-mediated increase in the level of the BAG3–HspB8 complex leads to upregulation of aggrephagy and clearance of irreversibly damaged proteins and might increase cell survival in conditions of hyperthermia.