Tania Zaglia

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The results indicate that the OPA1-dependent cristae remodeling pathway is a fundamental, targetable determinant of tissue damage in vivo.

TL;DR: This first report on the involvement of an area composita gene in ARVC shows that the pathogenesis of this disease extends beyond desmosomal proteins and might point to a causal relationship between CTNNA3 mutations and ARVC.

TL;DR: PI3K&ggr; blockade in models of mammary gland tumors prevented DOX-induced cardiac dysfunction and concomitantly synergized with the antitumor action of DOX by unleashing anticancer immunity.

TL;DR: Charged multivesicular body protein 2B (CHMP2B), which is part of an endosomal sorting complex required for autophagy, is identified as a target of atrogin-1-mediated degradation and downregulation in atrogan-1 KO mice restored autophileagy and decreased proteotoxicity, thereby preventing cell death.