Hongming Pan

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Understanding the novel function of autophagy may allow us to develop a promising therapeutic strategy to enhance the effects of chemotherapy and improve clinical outcomes in the treatment of cancer patients.

TL;DR: New insights are provided into p38 and JNK MAPK pathways function in the control of the balance of autophagy and apoptosis in response to genotoxic stress that will hopefully provide prospective strategies for cancer therapy.

TL;DR: Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagic model and also into cancer therapy, especially for the emerging targeted therapy, because a series of targeted agents execute antitumor activities via blockingSTAT3 signaling, which inevitably affects the autophile pathway.

TL;DR: Autophagy inhibition represents a promising approach to improve the efficacy of EGFR-TKIs in the treatment of patients with advanced non-small-cell lung cancer.