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Fulvio Chiacchiera

Researcher at European Institute of Oncology

Publications -  29
Citations -  6652

Fulvio Chiacchiera is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: Transcription factor & Autophagy. The author has an hindex of 17, co-authored 28 publications receiving 6019 citations. Previous affiliations of Fulvio Chiacchiera include University of Trento & University of Trieste.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells

Pietro Vella, +10 more
- 21 Feb 2013 - 
TL;DR: It is shown at a genome-wide level that Ogt preferentially associates with Tet1 to genes promoters in close proximity of CpG-rich transcription start sites, suggesting a link between Tet1 and Ogt activities in regulating C pG island methylation.
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The AMPK-FoxO3A axis as a target for cancer treatment.

Fulvio Chiacchiera, +1 more
- 15 Mar 2010 - 
TL;DR: This review focuses on the connections between AMPK and FoxO3A, describing their central role as modulators of fundamental processes such as stress resistance, cell metabolism, autophagy and cell death, and highlighting the therapeutic potential of pharmacological modulation of the AMPK-FoxO2A axis.
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p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

Fulvio Chiacchiera, +9 more
- 03 Apr 2009 - 
TL;DR: In vivo pharmacological blockade of p38α inhibits CRC growth in xenografted nude mice and azoxymethane-treated ApcMin mice, achieving both a cytostatic and cytotoxic effect, associated with high nuclear expression of FoxO3A and increased expression of its target genes p21 and PTEN.
Journal ArticleDOI

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

Fulvio Chiacchiera, +8 more
- 07 Jan 2016 - 
TL;DR: The data reveal that PRC1 preserves Wnt/β-catenin activity in adult stem cells to maintain intestinal homeostasis and supports tumor formation induced by the constitutive activation of this pathway.