scispace - formally typeset
Y

Yoshitaka Nagai

Researcher at Osaka University

Publications -  196
Citations -  12556

Yoshitaka Nagai is an academic researcher from Osaka University. The author has contributed to research in topics: Neurodegeneration & Gene. The author has an hindex of 46, co-authored 178 publications receiving 11303 citations. Previous affiliations of Yoshitaka Nagai include Kindai University & Kobe University.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

A toxic monomeric conformer of the polyglutamine protein.

Yoshitaka Nagai, +10 more
- 18 Mar 2007 - 
TL;DR: It is shown that aβ-sheet conformational transition of the expanded polyQ protein monomer precedes its assembly into β-sheet–rich amyloid-like fibrils and is a therapeutic target for polyQ diseases and possibly for conformational diseases in general.
Journal ArticleDOI

Glycolipids at the cell surface and their biological functions

Tamio Yamakawa, +1 more
- 01 Apr 1978 - 
TL;DR: A large variety of sphingoglycolipids occur at the surface of animal cells, and each glycolipid may exhibit a special function, as an annular lipid, receptor or surface marker and matrix lipid.
Journal ArticleDOI

Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic.

Toshiaki Takahashi, +5 more
- 01 Feb 2008 - 
TL;DR: Results indicate that a length-dependent formation of oligomers is an essential mechanism underlying neurodegeneration in polyQ-mediated disorders.
Journal ArticleDOI

GQ1b, a bioactive ganglioside that exhibits novel nerve growth factor (NGF)-like activities in the two neuroblastoma cell lines.

Shuichi Tsuji, +2 more
- 01 Jul 1983 - 
TL;DR: The results provide direct evidence for the participation of gangliosides in such functions as morphological and biochemical differentiation of neuronal cell cultures and the replacement of the effector function not only qualitatively but also quantitatively.