Jin H. Son

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Both the normal and pathophysiological roles of neuronal autophagy are considered and its potential therapeutic implications for common neurodegenerative diseases are considered.

TL;DR: It is found that the phylogenetically conserved Oxi‐α protects against OS by a novel mechanism: activation of the mammalian target of rapamycin (mTOR) kinase and subsequent repression of autophagic vacuole accumulation and cell death.

TL;DR: The results suggest that CHDH is required for PARK2-mediated mitophagy for the recruitment of SQSTM1 and LC3 onto the mitochondria for cargo recognition.