Kevin N. Dalby

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The data suggest that, depending on the cellular features, either the induction or the inhibition of autophagy can provide therapeutic benefits to patients and that the design and synthesis of the first-generation modulators of Autophagy may provide the tools for proof of concept experiments and the impetus for translational studies that may ultimately lead to new therapeutic strategies in cancer.

TL;DR: Ser222, Ser364, and Ser381 are situated in analogous positions to phosphorylation sites inprotein kinase B, protein kinase C, and p70S6K, suggesting a common mechanism of activation for these growth factor-stimulated protein kinases.

TL;DR: It is demonstrated that Cys273 of PP1 binds covalently to the methyl‐dehydroalanine (Mdha) residue of the toxin, which explains the failure to detect this toxin post‐mortem in suspected cases of MC poisoning.

TL;DR: The preliminary study suggests that implicit‐solvent based alchemical perturbation, which offers explicit sampling of configuration entropy, can be a viable approach to significantly improve the prediction of binding free energy.