Luisa Coletto

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Force activation of autophagy by genetic, dietary and pharmacological approaches restored myofiber survival and ameliorated the dystrophic phenotype of Col6a1−/− mice, indicating that defective activation of the autophagic machinery is pathogenic in some congenital muscular dystrophies.

TL;DR: It is shown that physical exercise activates autophagy in skeletal muscles, and these findings indicate that proper activation of Autophagy is important for muscle homeostasis during physical activity.

TL;DR: The present and previous results suggest a causal link between muscle atrophy, impaired skeletal muscle metabolism, impaired whole body oxidative metabolism, and insulin sensitivity and moderate inflammation, which are major risk factors of physical inactivity related diseases.

TL;DR: The current view on the role of autophagy lysosome and ubiquitin-proteasome in the pathogenesis of myopathies and muscular dystrophies is discussed, and how alteration of these degradative systems contribute to muscle wasting in inherited muscle disorders is discussed.