Trevor G. Shepherd

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Treatment of OvCa cells with BMP4 produced morphological alterations and increased cellular adhesion, motility and invasion, suggesting a link between autocrine BMP signalling mediated through the Rho GTPase family and Snail- and Slug-induced EMT that may collectively contribute to aggressive OvCa behaviour.

TL;DR: The laboratory has refined the technique for isolating primary cultures of normal human ovarian surface epithelial cells by combining two different protocols involving the enzymatic and mechanical removal of OSE cells from ovarian biopsies by including optional steps for the immediate preparation of ascites-derived EOC cells to be used for subsequent cytological analyses.

TL;DR: These findings imply that one or more of the PEA3 subfamily Ets proteins or other ETS proteins with related DNA binding specificity play an essential role in Neu-mediated mammary oncogenesis and agents that inhibit the expression or activity of the pea3 sub family proteins may prove efficacious in the treatment of breast cancer.

TL;DR: Artesunate has potent anti‐proliferative and cytotoxic effects on ovarian cancer cells, and may therefore be useful in the treatment of ovarian cancer.