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Stephen C. Pak

Researcher at Washington University in St. Louis

Publications -  71
Citations -  7712

Stephen C. Pak is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Serpin & Caenorhabditis elegans. The author has an hindex of 27, co-authored 63 publications receiving 6933 citations. Previous affiliations of Stephen C. Pak include Boston Children's Hospital & Icahn School of Medicine at Mount Sinai.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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C. elegans in high-throughput drug discovery.

Linda P. O’Reilly, +4 more
- 20 Apr 2014 - 
TL;DR: This review will outline the evolution of C. elegans-based drug screening, discuss the inherent challenges of using the organism, and highlight recent technological advances that have paved the way for future drug screens.
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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

Sager J. Gosai, +11 more
- 12 Nov 2010 - 
TL;DR: This study provides powerful validation for advancement in preclinical drug discovery campaigns by screening live C. elegans modeling α1-antitrypsin deficiency and other complex disease phenotypes on high-content imaging platforms.
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Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

Gary A. Silverman, +7 more
- 01 Feb 2004 - 
TL;DR: It is proposed that this cytoprotective function, along with similarities in structure are common features of a cohort of intracellular serpin clades from a wide variety of species.
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An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury

Cliff J. Luke, +14 more
- 21 Sep 2007 - 
TL;DR: It is suggested that multiple noxious stimuli converge upon a peptidase-driven, core stress response pathway that, in the absence of serpin regulation, triggers a lysosomal-dependent necrotic cell death routine.