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Lee Ann MacMillan-Crow

Researcher at University of Arkansas for Medical Sciences

Publications -  68
Citations -  9757

Lee Ann MacMillan-Crow is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Mitochondrion & Peroxynitrite. The author has an hindex of 34, co-authored 65 publications receiving 9090 citations. Previous affiliations of Lee Ann MacMillan-Crow include Baylor College of Medicine & United States Department of Veterans Affairs.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts

TL;DR: A role for peroxynitrite during development and progression of chronic rejection in human renal allografts is suggested, and inactivation of manganese superoxide dismutase by peroxlynitrite may represent a general mechanism that progressively increases the production of peroxysine nitration, leading to irreversible oxidative injury to mitochondria.
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Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues.

TL;DR: Observations are consistent with previous results using chronically rejecting human renal allografts and provide a compelling argument supporting the involvement of peroxynitrite during this pathophysiologic condition.
Journal ArticleDOI

Invited Review Manganese Superoxide Dismutase in Disease

TL;DR: The important role of MnSOD activity in various pathological states is assessed in light of this potentially lethal positive feedback cycle involving oxidative inactivation.
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Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite.

TL;DR: It is suggested that complete inactivation of MnSOD by ONOO- can occur independent of the active site tyrosine residue and includes not only nitration of critical tyrosines residues but also tyrosin oxidation and subsequent formation of dityrosine.