Kunikazu Tanji

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates called Lewy bodies (LBs) as discussed by the authors, which is considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs.

TL;DR: The histopathological hallmark of Parkinson’s disease is the presence of fibrillar aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent, and recent studies have indicated that nonfibrillars α- synuclein are cytotoxic and that fibrillsar aggregate ( LBs and pale bodies) may represent a cytoprotective mechanism in PD.

TL;DR: IFN‐γ‐induced production of galectin‐9 by endothelial cells may play an important role in immune responses by regulating interactions between the vascular wall and eosinophils.

TL;DR: Analysis of vibratome sections of brain tissue taken from normal human subjects suggests that a significant amount of alphaS is also present in the neuronal and glial cytoplasm in the normal human brain.