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Iwona A. Ciechomska

Researcher at Nencki Institute of Experimental Biology

Publications -  32
Citations -  6468

Iwona A. Ciechomska is an academic researcher from Nencki Institute of Experimental Biology. The author has contributed to research in topics: Autophagy & Glioma. The author has an hindex of 18, co-authored 29 publications receiving 5868 citations. Previous affiliations of Iwona A. Ciechomska include University of Cambridge.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function.

Iwona A. Ciechomska, +4 more
- 28 May 2009 - 
TL;DR: Although Beclin-1 contains a BH3-only motif typical of pro-APoptotic proteins, it is a negligible modulator of Bcl-2's anti-apoptotic function, arguing against compensation for the loss of protection by B cl-2 by autophagy-mediated survival induced by BeclIn-1.
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Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy.

Grazyna Mosieniak, +7 more
- 01 Jun 2012 - 
TL;DR: Inhibition of autophagy, due to the diminished expression of ATG5 by RNAi decreased the number of senescent cells induced by curcumin, but did not lead to increased cell death.
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Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine a-induced cell death.

Iwona A. Ciechomska, +3 more
- 21 Mar 2013 - 
TL;DR: The results demonstrate that CsA induces both apoptosis and autophagy in malignant glioma cells via induction of ER stress and inhibition of mTOR/p70S6K1 pathway, however Autophagy is cytoprotective in this context.
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Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells

Iwona A. Ciechomska, +3 more
- 23 Oct 2003 - 
TL;DR: Results indicate that downregulation of Akt signalling and activation of Forkhead is a prerequisite for the induction of FasL promoter, which may be clinically important for pharmacological intervention in gliomas.