Yuyan Xiong

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Arg‐II promotes macrophage proinflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis and Targeting Arg‐II represents a potential therapeutic strategy in type II diabetes mellitus and atherosclerosis.

TL;DR: A novel mechanism of mutual positive regulation between S6K1 and Arg‐II in endothelial inflammation and aging is revealed and may decelerate vascular aging and age‐associated cardiovascular disease development.

TL;DR: It is shown that overexpression of ARG2 in the young cells suppresses endothelial autophagy with concomitant enhanced expression of RICTOR, the essential component of the MTORC2 complex, leading to activation of the AKT-MTORC1-RPS6KB1/S6K1 cascade and inhibition of PRKAA/AMPK.