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F. Gisou van der Goot

Researcher at École Polytechnique Fédérale de Lausanne

Publications -  136
Citations -  16343

F. Gisou van der Goot is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Aerolysin & Palmitoylation. The author has an hindex of 54, co-authored 132 publications receiving 14612 citations. Previous affiliations of F. Gisou van der Goot include École Polytechnique & Goethe University Frankfurt.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Pore-forming toxins: ancient, but never really out of fashion

Matteo Dal Peraro, +1 more
- 01 Feb 2016 - 
TL;DR: The diverse pore architectures and membrane insertion mechanisms that have been revealed by structural studies of PFTs are discussed, and how these features contribute to binding specificity for different membrane targets are considered.
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Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

Laure Gurcel, +5 more
- 22 Sep 2006 - 
TL;DR: It is found that when rendered proteolytic in this context caspase-1 induces the activation of the central regulators of membrane biogenesis, the Sterol Regulatory Element Binding Proteins (SREBPs), which in turn promote cell survival upon toxin challenge possibly by facilitating membrane repair.
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Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

Laurence Abrami, +4 more
- 03 Feb 2003 - 
TL;DR: It is found that although endocytosis of ATR is slow, clustering it into rafts either via PA heptamerization or using an antibody sandwich is necessary and sufficient to trigger efficient internalization and allow delivery of LF to the cytoplasm.
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Targeting STING with covalent small-molecule inhibitors

Simone M. Haag, +10 more
- 04 Jul 2018 - 
TL;DR: The discovery and characterization of small-molecule antagonists that inhibit the stimulator of interferon genes (STING) protein may help to develop therapies for the treatment of autoinflammatory disease.