Zheng-Hong Qin

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Results support the idea that sequential proteolysis by caspase 3 and calpain may regulate huntingtin function at membranes and produce N-terminal mutant fragments that aggregate and cause cellular dysfunction in HD.

TL;DR: The discovery of the ATG genes in yeast has greatly advanced understanding of the molecular mechanisms participating in autophagy and the genes involved in regulating the autophagic pathway, suggesting that the basic machinery for autophile has been evolutionarily conserved along the eukaryotic phylum.

TL;DR: The involvement of BNIP3L/NIX in cerebral ischemia-reperfusion (I-R)-induced mitophagy is identified and insights into mitochondrial quality control in ischemic stroke are offered.

TL;DR: The evidence related to the interaction of Bcl-2 and Beclin 1 and the involvement of these proteins in human diseases such as cancers, neurodegenerative diseases and infectious diseases is summarized.