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Benedetto Grimaldi

Researcher at Istituto Italiano di Tecnologia

Publications -  37
Citations -  8673

Benedetto Grimaldi is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 22, co-authored 36 publications receiving 7868 citations. Previous affiliations of Benedetto Grimaldi include Sapienza University of Rome & University of California, Irvine.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

Yasukazu Nakahata, +7 more
- 25 Jul 2008 - 
TL;DR: It is proposed that SIRT1 functions as an enzymatic rheostat of circadian function, transducing signals originated by cellular metabolites to the circadian clock.
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CLOCK-mediated acetylation of BMAL1 controls circadian function

Jun Hirayama, +6 more
- 13 Dec 2007 - 
TL;DR: It is shown that CLOCK also acetylates a non-histone substrate: its own partner, BMAL1, is specifically acetylated on a unique, highly conserved Lys 537 residue, revealing the enzymatic interplay between two clock core components is crucial for the circadian machinery.
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PER2 controls lipid metabolism by direct regulation of PPARγ

Benedetto Grimaldi, +9 more
- 03 Nov 2010 - 
TL;DR: It is shown that PER2 directly and specifically represses PPARγ, a nuclear receptor critical in adipogenesis, insulin sensitivity, and inflammatory response, and that lack of PER2 results in enhanced adipocyte differentiation of cultured fibroblasts.
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Circadian clock regulates the host response to Salmonella

Marina M. Bellet, +12 more
- 11 Jun 2013 - 
TL;DR: The circadian clock modulates the inflammatory response during acute infection with the pathogen Salmonella enterica serovar Typhimurium and points to a clock-regulated mechanism of activation of the immune response against an enteric pathogen and may suggest potential therapeutic strategies for chronopharmacologic interventions.